Elpida Hadzi-Vasileva http://blog.elpihv.co.uk Mon, 19 Oct 2015 16:50:17 +0000 en-US hourly 1 http://wordpress.org/?v=3.9.17 Wellcome – Motilent http://blog.elpihv.co.uk/2015/10/wellcome-motilent-6/ http://blog.elpihv.co.uk/2015/10/wellcome-motilent-6/#comments Fri, 16 Oct 2015 09:04:31 +0000 http://blog.elpihv.co.uk/?p=1243 Last image shows a single time point from the dynamic series. Using powerful computer algorithms Motilent can quantify the motion caused by bowel motility to produce ‘motility maps’ (grayscale second image) and in colour (third image) where red shows areas of high motion and blue areas where there is low motility. First image is a fused image showing both the motility map and anatomy.

MapAM(1)

MATLAB Handle Graphics

MATLAB Handle Graphics

NormalVid

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Wellcome – Motilent http://blog.elpihv.co.uk/2015/10/wellcome-motilent-4/ http://blog.elpihv.co.uk/2015/10/wellcome-motilent-4/#comments Fri, 16 Oct 2015 09:02:25 +0000 http://blog.elpihv.co.uk/?p=1237 A dynamic ‘cine’ image of the small bowel and colon with MRI. The gastrointestinal tract is constantly moving and MR imaging allows us to visualise this process that frequently becomes deranged in disease.

HighHomo

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Wellcome- High resolution manometry http://blog.elpihv.co.uk/2015/10/wellcome-motilent-3/ http://blog.elpihv.co.uk/2015/10/wellcome-motilent-3/#comments Mon, 12 Oct 2015 21:14:19 +0000 http://blog.elpihv.co.uk/?p=1228 High resolution, invasive, optical manometry that detects pressure changes inside the bowel.

(A) A condensed manometric recording of the colon of a single subject over a 2-h period (1 h before and after a meal). The white line in the middle of the trace shows where the subject started the meal. Note the rapid increase in number of pressure events after the meal. (B) It is an enlargement of the red hatched box in A. Numerous retrograde cyclic propagating motor patterns are visible; they clearly comprise majority of the increased contractile activity induced by the meal. (C) It shows the same data as seen in B, but shown as a traditional low-resolution trace (lines spaced at 7 cm). All propagation is lost and these data would have been labeled as ‘non-propagating’. (Neurogastroenterol Motil (2014) 26, 1443–1457)

Neurogastroenterology and Motility

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Wellcome – High resolution manometry http://blog.elpihv.co.uk/2015/10/wellcome-motilent-2/ http://blog.elpihv.co.uk/2015/10/wellcome-motilent-2/#comments Mon, 12 Oct 2015 21:14:00 +0000 http://blog.elpihv.co.uk/?p=1231 High resolution, invasive, optical manometry that detects pressure changes inside the bowel.

Examples of the five main types of propagating motor pattern identified by visual inspection of multi-channel manometric traces. (A) High-amplitude propagating sequence; (B) cyclic propagating motor pattern, in this instance propagating in an retrograde (oral) direction (blue arrow); (C) short single propagating motor pattern – in this case moving in a retrograde direction (blue arrow); (D) long single propagating motor pattern – all of these moved in an antegrade (anal) direction (blue arrow). (E) Slow retrograde propagating motor pattern (blue arrow), which was only observed in two subjects, and only during the fasted state.
(Neurogastroenterol Motil (2014) 26, 1443–1457)

Neurogastroenterology and Motility_1

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Wellcome – Motilent http://blog.elpihv.co.uk/2015/10/wellcome-motilent/ http://blog.elpihv.co.uk/2015/10/wellcome-motilent/#comments Mon, 12 Oct 2015 20:38:20 +0000 http://blog.elpihv.co.uk/?p=1225 GIQuant is Motilent’s bowel motility analysis technology that allows objective, quantitative analysis of MRI motility images. The grid represents ‘deformation fields,’ a mathematical description of how the bowel is moving. Areas of greater deformation correspond to higher motility and vice versa. GIQuant has been used to demonstrate motility changes arising from pathology in a range of conditions like Crohn’s disease.

grid_Normal

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Wellcome – UCL http://blog.elpihv.co.uk/2015/10/wellcome-ucl-32/ http://blog.elpihv.co.uk/2015/10/wellcome-ucl-32/#comments Mon, 12 Oct 2015 20:30:09 +0000 http://blog.elpihv.co.uk/?p=1222 With Dr Caroline Pallet-Many – Aortic valve atherosclerosis NRPI (brown) immunohistochemistry

J_57aR NRP1

K_76aL neg

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Wellcome – UCL http://blog.elpihv.co.uk/2015/10/wellcome-ucl-31/ http://blog.elpihv.co.uk/2015/10/wellcome-ucl-31/#comments Mon, 12 Oct 2015 20:28:40 +0000 http://blog.elpihv.co.uk/?p=1220 With Dr Caroline Pallet-Many – Aortic valve atherosclerosis NRPI (brown) immunohistochemistry

I_aortic valve with atherosclerosis NRP1

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Wellcome – UCL http://blog.elpihv.co.uk/2015/10/wellcome-ucl-30/ http://blog.elpihv.co.uk/2015/10/wellcome-ucl-30/#comments Mon, 12 Oct 2015 20:26:28 +0000 http://blog.elpihv.co.uk/?p=1218 With Dr Caroline Pallet-Many – Mouse ear mark 15 days. DOPPLER image showing staining blood. How in mouse leg 15 days after HLI (Hindlimb schema) induction growth of new vessels.

H_mouse ear mark 15 days (Flux)

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Wellcome – UCL http://blog.elpihv.co.uk/2015/10/wellcome-ucl-29/ http://blog.elpihv.co.uk/2015/10/wellcome-ucl-29/#comments Mon, 12 Oct 2015 20:24:14 +0000 http://blog.elpihv.co.uk/?p=1216 With Dr Caroline Pallet-Many – SMA (smooth muscle actin) in green and blue = nuclei DAPI

F_090915_SMA 14d 2_z0

G_090915_SMA-FITC 14 d_z0

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Wellcome – UCL http://blog.elpihv.co.uk/2015/10/wellcome-ucl-28/ http://blog.elpihv.co.uk/2015/10/wellcome-ucl-28/#comments Mon, 12 Oct 2015 20:21:47 +0000 http://blog.elpihv.co.uk/?p=1214 With Dr Caroline Pallet-Mny – LCA 14 days after surgery

C_LCA44DC7

D_LCA44DC7

LCA 28 days after surgery

E_LCA12WT28

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