Category Archives: Wellcome Trust

‘Making Beauty’ is a collaboration to create a series of artworks in new materials. I’m working in partnership with Dr Richard Day and Professor Alastair Forbes and their colleagues at University College Hospital, London and University of East Anglia, Norwich. The project is a creative response to pioneering therapeutic device developments for regenerative therapy in the context of nutrition and health, and includes the aim of encouraging audiences to consider and examine the ethics of medical research. The projects compliments and extends my continuing interest in the application of unusual materials for art works.
‘Making Beauty’ is being developed with funding from The Wellcome Trust with curatorial support from Gill Hedley and advice from Mark Segal, both also acting as critical friends.

Wellcome – Motilent

Last image shows a single time point from the dynamic series. Using powerful computer algorithms Motilent can quantify the motion caused by bowel motility to produce ‘motility maps’ (grayscale second image) and in colour (third image) where red shows areas of high motion and blue areas where there is low motility. First image is a fused image showing both the motility map and anatomy.

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MATLAB Handle Graphics

MATLAB Handle Graphics

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Wellcome- High resolution manometry

High resolution, invasive, optical manometry that detects pressure changes inside the bowel.

(A) A condensed manometric recording of the colon of a single subject over a 2-h period (1 h before and after a meal). The white line in the middle of the trace shows where the subject started the meal. Note the rapid increase in number of pressure events after the meal. (B) It is an enlargement of the red hatched box in A. Numerous retrograde cyclic propagating motor patterns are visible; they clearly comprise majority of the increased contractile activity induced by the meal. (C) It shows the same data as seen in B, but shown as a traditional low-resolution trace (lines spaced at 7 cm). All propagation is lost and these data would have been labeled as ‘non-propagating’. (Neurogastroenterol Motil (2014) 26, 1443–1457)

Neurogastroenterology and Motility

Wellcome – High resolution manometry

High resolution, invasive, optical manometry that detects pressure changes inside the bowel.

Examples of the five main types of propagating motor pattern identified by visual inspection of multi-channel manometric traces. (A) High-amplitude propagating sequence; (B) cyclic propagating motor pattern, in this instance propagating in an retrograde (oral) direction (blue arrow); (C) short single propagating motor pattern – in this case moving in a retrograde direction (blue arrow); (D) long single propagating motor pattern – all of these moved in an antegrade (anal) direction (blue arrow). (E) Slow retrograde propagating motor pattern (blue arrow), which was only observed in two subjects, and only during the fasted state.
(Neurogastroenterol Motil (2014) 26, 1443–1457)

Neurogastroenterology and Motility_1

Wellcome – Motilent

GIQuant is Motilent’s bowel motility analysis technology that allows objective, quantitative analysis of MRI motility images. The grid represents ‘deformation fields,’ a mathematical description of how the bowel is moving. Areas of greater deformation correspond to higher motility and vice versa. GIQuant has been used to demonstrate motility changes arising from pathology in a range of conditions like Crohn’s disease.

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